Executive producer of The Flash, Andrew Kreisberg, said a few things at the PaleyFest panels in Los Angeles that makes us believe the showrunners are planning to bring the Flashpoint storyline into the mix.
During a question and answer session, a fan asked Kreisberg if the writers plan to go deeper into the DC Comics lore, and to this, he answered saying, "There's a fairly big Flash storyline from the comics that were going to tackle in the future."
If we had to guess, Kreisberg could be talking about the popular Flashpoint storyline that saw The Flash going back in time to save his mother. As the story goes, he achieved this, but only to find out that he changed the future all for the worst.